Syntheses of biologically active molecules and development of new synthetic methodologies

نویسندگان

  • Antoni Riera
  • Xavier Verdaguer
چکیده

Our group focuses on synthesising biologically active compounds for the various stages of drug development. Several of our projects are devoted to the development of basic synthetic methodology, with a special emphasis on asymmetric synthesis, while others address the synthesis of compounds of known therapeutic interest, in which emphasis is placed on the reliability, efficiency and scalability of the processes. Finally, other projects underway are related to drug discovery; these aim to prepare new compounds for biological screening. Syntheses of biologically active molecules and development of new synthetic methodologies Antoni Riera

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Synthesis of biologically active molecules and development of new synthetic methodologies

Catalytic and asymmetric reactions. Basic synthetic methodologies New developments in the Pauson-Khand reaction The Pauson-Khand reaction (PKR) is one of the most powerful reactions for the preparation of cyclopentanic compounds. The PKR is a cobalt-promoted or -catalysed cycloaddition between an alkene and an alkyne with the insertion of a carbon monoxide molecule to give a cyclopentenone. We ...

متن کامل

Influence of Natural Sources of Biologically Active Substances on Livestock and Poultry Reproduction

Synthetic hormones and bioactive substances (vitamins, pigments and isoflavons) which have been used in the feed industry are accumulated in milk, meat and eggs. It is suspected that these are responsible for a number of side-effects such as carcinogenesis, liver and kidney damage, allergies in consumers. Furthermore the synthetic hormones, vitamins, pigments are less active than those extracte...

متن کامل

Over Expression of Biologically Active Interferon Beta Using Synthetic Gene in E. coli

In this study, our previously reported novel synthetic gene encoding 166 residues of interferon-? was used for an efficient expression of IFN-?. The synthetic gene was cloned into pET21a expression vector and transferred into E. coli. Recombinant protein was over-expressed in the E. coli. Identity of the recombinant protein was confirmed by western blot analysis. The recombinant protein was bio...

متن کامل

Three Component Syntheses of Pyrrolo Imidazole Derivatives in the Presence of N-methyl imidazole, Activated Acetylenes and Phenylsulfonylacetophenone

Because of the significant role in biological processes in living cells and the diverse types of physiological activities, heterocyclic compounds are in focus of intense investigations by academic, industry and applied-oriented chemists. Considerably, ascientific renaissance of heterocycles during the last decades is closely related to the development of multicomponent approaches to their s...

متن کامل

Spotlight- Molecular iodine

Mayuri M. Naik was born in 1988 in Curchorem, Goa (India). She completed her B.Sc. from Government College of arts, science and commerce, Quepem-Goa in 2008. She received her M.Sc. degree in organic chemistry from Goa University in 2010. Presently she is proceeding with Ph.D. under the supervision of Prof. S. G. Tilve and Prof. V. P. Kamat in department of chemistry, Goa University, Goa. Her re...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2010